Influence of polypropylene mesh on local and systemic production of cytokines during thoracoplasty in experiment

Introduction. The question of the body's immune reactivity when using mesh implants for plastic surgery chest frame remains not fully understood.Aims. effect polypropylene endoprosthesis "Surgipro" on systemic and local cytokine production after reconstruction was evaluated.Materials methods. work performed male Wistar rats weighing 250 50 grams (n=21). main group consisted with musculo-aponeurotic plasty (n=9), comparison animals that underwent removal posterior segment IV rib measuring 1.0 cm overlapping over (n=9). Healthy without served as control (n=3). were taken out experiment days 1, 10 30 operation. Determination cytokines TNF-, IFN- IL-10 in blood serum biopsy postoperative scar by method enzyme-linked immunosorbent assay.Results. It found experiment, affects IL-10. A more intense increase anti-inflammatory recorded use implant (p˃0.05). At same time, at values below (p˃0.05).Conclusions. conducted experimental study revealed a restoration defect thoracic causes pronounced reduces